Heterochromatin protein 1 - Wikipedia
HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of SIR (silent information regulatory) proteins serve a similar function.
Heterochromatin protein 1 (HP1): interactions with itself and …
Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the ...
Nature | 核小体构象变化与异染色质相分离 - 知乎
异染色质中最主要的一类是由组蛋白H3第九位赖氨酸甲基化（H3K9me）修饰的异染色质。H3K9me招募HP1（Heterochromatin protein 1）蛋白，对染色质进行压缩形成异染色质区域。
HP1: Heterochromatin binding proteins working the genome
Heterochromatin Protein 1 (HP1) is a transcriptional repressor that directly binds to the methylated lysine 9 residue of histone H3 (H3K9me), which is a hallmark histone modification for transcriptionally silenced heterochromatin.
Functions of HP1 proteins in transcriptional regulation
2022年5月7日 · Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety of molecular mechanisms. HP1 proteins are highly conserved, and many eukaryotic genomes contain multiple HP1 genes.
The Heterochromatin Protein 1 family - Genome Biology
2006年7月21日 · Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species.
Heterochromatin protein 1 (HP1) is intrinsically required for post ...
2019年3月13日 · HP1 is a dynamic epigenetic determinant mainly involved in heterochromatin formation, epigenetic gene silencing and telomere maintenance. Furthermore, recent studies have revealed the importance...
HP1 and the dynamics of heterochromatin maintenance
2004年4月1日 · At the molecular level, a prominent mark of pericentric heterochromatin is its enrichment in heterochromatin protein-1 (HP1). The multipartite organization of HP1 enables it to bind to...
The Heterochromatin Protein 1 (HP1) Family: Put Away a Bias toward HP1
2008年9月1日 · Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein with dose-dependent effect on gene silencing. The HP1 family is evolutionarily highly conserved and there are multiple members within the same species.
Heterochromatin protein 1 (HP1): interactions with itself
2020年3月6日 · Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation.