Mechanisms of DNA damage, repair and mutagenesis - PMC
In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells …
DNA damage repair: historical perspectives, mechanistic pathways and ...
2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we …
Genetic Damage - an overview | ScienceDirect Topics
The genetic damage that results in cancer can occur in several ways: translocations of genes can juxtapose two genes in ways that cause dysregulation of their function; mutations can activate …
The central role of DNA damage in the ageing process - Nature
2021年4月28日 · Cellular and tissue consequences of DNA damage include cell fate decisions such as cell death and senescence, leading to functional loss of cells and organs, cancer, …
Genetics, DNA Damage and Repair - StatPearls - NCBI Bookshelf
2023年8月14日 · Unfortunately, the DNA is at constant risk of mutation, which means a change to the genetic information in a cell, and this can happen due to a variety of factors. [1] One must …
Exploring DNA Damage and Repair Mechanisms: A Review with …
2024年1月24日 · DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related …
DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity
DNA integrity is always under attack from environmental agents like skin cancer-causing UV rays. How do DNA repair mechanisms detect and repair damaged DNA, and what happens when …
DNA Damage: From Threat to Treatment - PMC - PubMed …
The genome is continuously threatened by different types of DNA lesions, such as abasic sites, mismatches, interstrand crosslinks, or single-stranded and double-stranded breaks. As a …
A Genetic Map of the Response to DNA Damage in Human Cells - Cell …
2020年7月9日 · The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity, and gametogenesis. In order to provide an unbiased and global view …
Methods and applications of genome-wide profiling of DNA damage …
2024年6月25日 · DNA damage refers to any alteration in the chemical structure of DNA and can result from endogenous or exogenous processes 1, 2. Different processes cause different …