Cellular Senescence in Sarcopenia: Possible Mechanisms and …
2022年1月9日 · Cellular senescence has been implicated in chronic low-grade sterile inflammation, also known as inflammaging in sarcopenia, a hallmark of the ageing process, whereby the senescence-associated secretory phenotype (SASP), which transforms the microenvironment and impinges on the surrounding cells.
Cellular Senescence in Sarcopenia: Possible Mechanisms and
2022年1月10日 · Cellular senescence refers to the essentially irreversible growth arrest mainly regulated by p53/p21 CIP1 and p16 INK4a /pRB pathways as organism ages, possibly detrimentally contributing to sarcopenia via muscle stem cells (MuSCs) dysfunction and the senescence-associated secretory phenotype (SASP) …
Sarcopenia, obesity, and natural killer cell immune senescence in …
We review the effect that adipokines and myokines have on NK cells, with special emphasis on IL-15. We posit that increased adipokine and decreased IL-15 levels during aging constitute a common mechanism for sarcopenia, obesity, and immune senescence. Human aging is characterized by both physical and physiological frailty.
Cellular Senescence: The Driving Force of Musculoskeletal Diseases
Cellular senescence contributes to the aging of muscle tissue and the onset of sarcopenia. Cellular senescence in sarcopenia is a process in which specific senescence markers, such as p16, p21, and p53, block the cell cycle by inhibiting the growth and proliferation of satellite cells.
Skeletal muscle as potential central link between sarcopenia and immune ...
2019年10月26日 · Aging of skeletal muscle is central in the pathogenesis of immune senescence and sarcopenia. Multiple pathways are affected, including insufficient myokine signalling (IL-6, IL-7, IL-15), shifting of membrane bound immune regulatory factors towards a pro-inflammatory profile, impaired immune cell function and altered body composition.
Regenerative decline of stem cells in sarcopenia - ScienceDirect
2016年8月1日 · Activated stem cells need to coordinate two basic functions: self-renew a new stem cell by re-instating quiescence and thus ensuring the maintenance of the stem cell pool; and differentiate to give rise to a specialized mature progeny that can replenish the lost cells with specialized functions in the renewing or regenerating tissue.
Cellular senescence in musculoskeletal homeostasis, diseases, and ...
2021年9月10日 · Tocotrienol-rich fraction treatment of patients with sarcopenia has been shown to reverse myoblast aging and senescence, providing muscle cells with the regenerative capacity needed to...
A Senescence-Centric View of Aging: Implications for ... - Cell Press
2020年8月13日 · Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential.
Cellular Senescence in Sarcopenia: Possible Mechanisms
We review the possible mechanisms involved in muscle stem cells (MuSCs) dysfunction and the SASP resulting from cellular senescence, their associations with sarcopenia, current emerging therapeutic opportunities based on targeting cellular senescence relevant to sarcopenia, and potential paths to developing clinical interventions genetically or ...
Cellular senescence in musculoskeletal homeostasis, diseases, …
2021年9月10日 · In this review, we summarize evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders, including osteoporosis, osteoarthritis, and sarcopenia.