When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

As the Bills face off against the 49ers in Week 13, their defense looks to get a noticeable boost, as the team activated LB ...

Rookie coach Mike Macdonald has promoted multiple reserves, rookies, practice-squad players to prominent roles from ...

Meteorologists are projecting 20 to 30 inches of snow to fall in Orchard Park, NY before kickoff between the San Francisco ...

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.

Heavy lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

Lake-effect snow also covered parts of Michigan’s Upper Peninsula in a system that is expected to last through the weekend.

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

The 49ers don't know when their their Hall of Fame left tackle's ankle will heal. The team listed Trent Williams as out for the second game in a row ...

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...