Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United ...
This suggests that regulating gene activity is not the only function of these histone decorations — perhaps not even the main one. The histone proteins of complex cells are named H2A, H2B, H3 and H4.
EZH2 is also capable of methylating a number of non-histone protein substrates, such as STAT3, which promotes PD-L1 expression in tumor cells. In addition, EZH2 has a PRC2-independent role in ...
Penn Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Department of ...