Mutational signature analyses of de novo mutations in multi-child human families suggest that inaccurate DNA mismatch repair, DNA damage, and replication errors are major sources of age-related ...

When the gene that codes for EGFR has a mutation, it affects the way this protein works, causing cancer. There are many types of EGFR mutations. The EGFR protein lives in the cell membrane with ...

By deciphering the human genetic code, scientists were hopeful to learn more about diseases linked to specific mutations and variations in this genetic script. Given that the human genome ...

By deciphering the human genetic code, scientists were hopeful to learn more about diseases linked to specific mutations and variations in this genetic script. Given that the human genome ...

Oncogenic mutations often involve single nucleotide substitutions at specific hotspots, leading to hyperactive or gain-of-function variants. Tumor suppressor mutations typically involve indels ...

Cheng explains. This becomes even more complicated when disease-causing DNA mutations are introduced into the mix. Some genes can be mutated in many ways to cause the same disease, meaning one ...

For the Beta variant, the 484th position showed a mutation rate over 60% with E484K. The Delta variant showed a mutation rate of 60% at the 452nd position. L452R and T478K amino acid substitutions ...

The research, published in the journal Nature Medicine, noted that the vaccine is effective against coronavirus variants carrying the N501Y and E484K mutations. AstraZeneca said it is yet to be fully ...

Here, we present a mosaic-type trimeric form of spike receptor-binding domain (mos-tri-RBD) as a broad-spectrum vaccine candidate, which carries the key mutations from Omicron and other circulating ...

An estimated 56.5 percent of the patients contracted a variant with the E484K mutation, which is feared to reduce vaccines’ efficacy. The two variants accounted for 89 percent of the infections ...