Here are the Week 13 games that will impact the 49ers’ playoff chances and which team the 49ers need to win: 49ers need: A ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

There is a High Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the San Francisco 49ers ...

San Francisco 49ers coach Kyle Shanahan explained why star linebacker Dre Greenlaw is participating in "mock games" during ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The Pittsburgh Steelers and Cleveland Browns had one of the most picturesque games in NFL history last Thursday night when ...

San Francisco 49ers running back Christian McCaffrey is three games into his return from injury. The two-time first-team ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...