San Francisco 49ers star quarterback Brock Purdy has been given an injury update in time for their Week 13 match up against ...

Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

The San Francisco 49ers have been dealing with injury issues all season, but Week 12's game against the Green Bay Packers f ...

The Buffalo Bills played the Kansas City Chiefs in their last game before heading into the bye week. They pulled off the ...

The San Francisco 49ers will face a steep uphill battle Sunday when they face the Green Bay Packers at Lambeau Field.

The Buffalo metro area is in the middle of a lake-effect snow warning lasting until 7 p.m. ET on Monday. The National Weather ...

Tom Brady is back in the booth for a Packers game for the second week in a row, and it's a big one against the 49ers.

After missing Week 11 against the Seattle Seahawks, San Francisco 49ers tight end George Kittle is off the injury report and ...