It seems like Trent Williams will miss his second game in a row this weekend with an ankle injury. Williams didn't practice ...

San Francisco 49ers left tackle Trent Williams may be at risk of missing his second consecutive game. On Sunday, the offensive lineman was sidelined against the Green Bay Packers due to an ankle ...

San Francisco 49ers offensive tackle Trent Williams was seen in the locker room on Wednesday using a scooter as he recovers ...

San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there ...

The San Francisco 49ers received important Brock Purdy, Trent Williams and Nick Bosa injury updates on Wednesday.

On his “Cleats and Convos with Deebo Samuel” podcast, Deebo Samuel was asked about the idea that Kyle Shanahan could be out at the end of the year.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Bills: The Buffalo Bills were off in Week 12, so they didn’t move in our rankings. They are still the clear No. 2 team in the ...

The Bills return from their bye week with a tough test on Sunday Night Football. Here's a look ahead to the matchup.

The 49ers are taking stock of their injury situation but expect to get some key players back on the practice field.

Listen in as 49ers tight end George Kittle was wired for sound during San Francisco's Week 12 matchup against the Green Bay ...

The 49ers have been careful not to open practice windows for any of their players too early. With that in mind, if everything ...