The Lions have a long history of misery. They're also Super Bowl favorites for the first time in franchise history.

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 ...

SANTA CLARA — While Brock Purdy resumed practicing through a shoulder issue and Dre Greenlaw made a much-anticipated debut ...

When Kamala Harris and Donald Trump campaigned in North Carolina, both candidates courted a state-recognized tribe there ...

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.

DK Metcalf is supporting two organizations this season, Prison Fellowship and SOUND, for the NFL’s My Cause My Cleats ...

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

City, county and state officials are preparing for whatever the weather system has in store for Western New York.

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

Tua Tagovailoa was sidelined after suffering a concussion in Week 2 - with the Miami Dolphins star having since returned to ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Milano practiced without a red non-contact jersey for the first time since his bicep injury in August and was listed on the ...