Jake Retzlaff ran for two touchdowns and threw for 167 yards to lead No. 19 BYU to a 30-18 victory over Houston.

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

According to ESPN's Adam Schefter, San Francisco 49ers quarterback Brock Purdy (shoulder) is anticipated to play in Sunday ...

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

The arrow is pointing upward for Brock Purdy. On Friday, the 49ers delivered encouraging news on Purdy's status vs Buffalo in ...

Los Angeles Chargers (7-4) at Atlanta Falcons (6-5), 1 p.m. ET, FOX Atlanta holds a one-game lead over the Tampa Bay Buccaneers in the NFC South but lost the last ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...