The San Francisco 49ers have slim playoff hopes of their own, but they can also play spoiler against the Buffalo Bills in ...

As the 49ers prepare for their Week 13 matchup against the Bills, Brock Purdy will be the signal caller after being listed as ...

Jake Retzlaff ran for two touchdowns and threw for 167 yards to lead No. 19 BYU to a 30-18 victory over Houston.

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

According to ESPN's Adam Schefter, San Francisco 49ers quarterback Brock Purdy (shoulder) is anticipated to play in Sunday ...

It looks like the San Francisco 49ers might get their quarterback back under center in time for a Week 13 matchup with the ...

Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...