Meteorologists are projecting 20 to 30 inches of snow to fall in Orchard Park, NY before kickoff between the San Francisco ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

The San Francisco 49ers have slim playoff hopes of their own, but they can also play spoiler against the Buffalo Bills in ...

Heavy lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

The 49ers have revealed their latest injury report from Wednesday’s practice before their Sunday Night Football tilt against ...

The Buffalo Bills played the Kansas City Chiefs in their last game before heading into the bye week. They pulled off the ...

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...

Break out the shovels, Bills Mafia. Meteorologists are anticipating upwards of a foot of snow to fall atop Orchard Park prior to the Buffalo Bills’ primetime Week 13 bout with the San Francisco 49ers, ...

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

San Francisco 49ers running back Christian McCaffrey (23) fumbles the ball against the Green Bay Packers during their ...

The Packers took care of business against the shorthanded 49ers Sunday, but the celebration is only temporary.