Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation).

New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these ...

If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding ...

But Storici's team found that RNA can also help cells repair a severe form of DNA damage called a double-strand break, or DSB. A DSB means both strands of the DNA helix have been severed.

Healthcare - The exploration of peptides as bioregulatory molecules has gained considerable attention in recent years, with a ...

The eukaryotic genome is organized in the form of a highly compact nucleoprotein complex, the chromatin. Nucleosome, the basic unit of chromatin, consists of ~147 bp of DNA wrapped 1.65 times around a ...

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After hours: November 29 at 4:56 PM EST Loading Chart for DNA ...