One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

San Francisco 49ers coach Kyle Shanahan explained why star linebacker Dre Greenlaw is participating in "mock games" during ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

San Francisco 49ers running back Christian McCaffrey is three games into his return from injury. The two-time first-team ...

The Pittsburgh Steelers and Cleveland Browns had one of the most picturesque games in NFL history last Thursday night when ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

This is the fifth time the Bills are playing in prime-time this year and they are 3-1, though the loss did come in their only ...