Loss of core histones is now observed in aged cells and may contribute to this phenomenon. Histone loss is coupled to cell division and seems to be triggered by telomeric DNA damage. Figure 2 ...

How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a family of small, positively charged proteins termed H1, H2A, H2B, H3, and H4 (Van Holde ...

A proposed method for DNA demethylation involves sequential oxidation and deamination of 5mC, followed by base excision repair 1. A second epigenetic mechanism implicated in learning and memory ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...

Histones proteins were selected early in ... mechanisms for the control of gene expression, as well as for DNA replication, ...