The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

Genes make up the blueprints and outline the process of building every living organism. To ensure that the right genes are ...

For the first time, Northwestern Medicine scientists have identified a population of long-lived proteins in the ovaries which ...

Thousands of scientists and plant breeders have since used that genome in their own research on the genetic makeup underlying ...

A major challenge in this field has been figuring out which histones have which chemical modifications, where on the histone ...

This work will be of high interest to a broad swathe of scientists studying native macromolecules present at low concentrations in cells. Cryo-EM single-particle analyses typically require target ...

Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. Adenoviruses encode their own histone-like protein, called protein VII, that forms a ...

EZH2 is also capable of methylating a number of non-histone protein substrates, such as STAT3, which promotes PD-L1 expression in tumor cells. In addition, EZH2 has a PRC2-independent role in ...

Our group retains an interest in the areas of structure-function studies of RNA interference mediated by siRNA pathway, and on post-translation histone and DNA modifications impacting on epigenetic ...