The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

Genes make up the blueprints and outline the process of building every living organism. To ensure that the right genes are ...

For the first time, Northwestern Medicine scientists have identified a population of long-lived proteins in the ovaries which ...

A major challenge in this field has been figuring out which histones have which chemical modifications, where on the histone ...

So what accounts for the thickness? The DNA is wrapped around spools of a protein called histone. The histone, in turn, forms large loops. So the DNA is much, much longer than the chromosome it ...

This work will be of high interest to a broad swathe of scientists studying native macromolecules present at low concentrations in cells. Cryo-EM single-particle analyses typically require target ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...