The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

Nuclear condensates play many important roles in chromatin functions, but how cells regulate their nucleation and growth within the complex nuclear environment is not well understood. Here, we report ...

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

cfDNA coverage shows an inverse relationship with both chromatin accessibility and gene expression levels, Using this relationship and machine learning identify patients with cancer.

Although epigenetic phenomena have been observed for over a century, researchers have only started to untangle their underlying mechanism and effects on gene expression. This course provides and ...

Every day, our cells divide. Each time they need to copy both their DNA and the structure in which the DNA is packed. This ...

In a recent paper published in the journal Genome Research, experts described the chromatin arrangement in the genomes of two ...

Cell-free DNA can be used for non-invasive cancer detection and disease monitoring to enhance personalized medicine.