Cellular senescence is a stress-response program (Figure 1) that is potentially tumor suppressive. We previously showed that senescence arises through chromatin remodeling that silences proliferative ...

Cornell University researchers have created a detailed understanding of how muscles lose their ability to regenerate as they age, using mice as a model. They identified 29 cell types and found that ...

As muscles age, their cells lose the ability to regenerate and heal after injury. Researchers have created the most ...

For the first time, researchers have discovered that the accumulation of aged and failing cells, called senescent cells, in ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...