Cellular senescence is a stress-response program (Figure 1) that is potentially tumor suppressive. We previously showed that senescence arises through chromatin remodeling that silences proliferative ...

Interventions that target one of the pillars, cellular senescence, for example, tend to result in reduced inflammation, decreased fibrosis, and restoration of the microbiome in animal trials.

The research focuses on cellular senescence, a process where cells stop dividing and enter a state associated with chronic ...

As muscles age, their cells lose the ability to regenerate and heal after injury. Researchers have created the most ...

For the first time, researchers have discovered that the accumulation of aged and failing cells, called senescent cells, in ...

As muscles age, their cells lose the ability to regenerate and heal after injury. Now, Cornell University researchers have created the most comprehensive portrait to date of how that change, in mice, ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...