The San Francisco 49ers entered this season with lofty aspirations. For the most part, their hopes have been dashed -- and ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

Suddenly, the Niners' starting running back on Sunday against the Chicago Bears will be rookie Isaac Guerendo with practice ...

The San Francisco 49ers' dreadful season got worse in Week 13 when running backs Christian McCaffrey and Jordan Mason both ...

The 49ers are down to one healthy RB, rookie Isaac Guerendo. They will likely elevate Patrick Taylor Jr. from the practice ...

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

The Los Angeles Rams' bitter rival San Francisco 49ers just received news that their All-Pro running back Christian McCaffrey ...

McCaffrey suffered a PCL injury during Sunday's loss to the Bills, while Mason went on IR with a high ankle sprain.

San Francisco 49ers star running back Christian McCaffrey suffered a PCL injury and is expected to miss six weeks, head coach ...